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Glucagon-like peptide 1 receptor (GLP-1R), on the other hand, is primarily expressed in the pancreas, gut, central nervous system, and also found in other tissues like the heart, kidneys, and lungs

This review examines the neuroprotective potential and metabolic effects of GLP-1 RAs in PD, with particular emphasis on their impact on weight regulation, underlying mechanisms, clinical outcomes, and therapeutic prospects

The program runs from July 1, 2026 through December 31, 2027

Tirzepatide is a dual GIP/GLP-1 receptor agonist administered as a weekly subcutaneous injection, producing up to 20.9% weight loss at 72 weeks in Phase 3 trials