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The greatest weight loss is usually seen after a year, and people without diabetes tend to lose more weight than those with diabetes

In the STEP 1 trial, about 10% of participants achieved less than 5% weight loss, roughly the same as placebo response

Increased physical activity can help preserve muscle while reducing body fat, which may result in smaller clothing sizes even when scale weight changes slowly

Compounded drugs can help in certain cases, but theyre not always safe

Still, Pfizer and Roches success here will depend on many factors, including the outcome of clinical trials, advancements in drug pipelines, the demonstrated efficacy and safety of their candidates, and effective strategies for commercialization and market access