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While both medications are GLP-1 agonists that promote weight loss, Ozempic has demonstrated greater effectiveness in clinical trials

Trial data shows mild to moderate gastrointestinal issues such as nausea, vomiting, and diarrheacommon with GLP-1 medications

However, when food sits in the stomach for a longer duration, the stomach continues to produce acid to break it down

Semaglutide tablets have been available in the UK since 2020 for the treatment of type 2 diabetes under the brand name Rybelsus and are used globally by millions of people

Sema has an ameliorative effect on metabolic disorders in patients with obesity, but the mechanism is unknown