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Manufacturing method matters

For highly sensitive individuals, even one-tenth of the therapeutic concentration may produce noticeable appetite modulation

Individual variation in GLP-1 receptor density and sensitivity means some people tolerate these changes quickly while others require longer adjustment periods or dose titration strategies

Once-weekly exenatide: an extended-duration glucagon-like peptide agonist for the treatment of type 2 diabetes mellitus

A robust sandwich covariance matrix estimator was used in the Cox model analyses to account for the re-use of stable use sets of insulin in the matching for GLP-1RA users (Additional file 1: Fig