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In the current review, we discussed the dysregulation of IGF-1/GLP-1 signaling in neurodegenerative manifestations of ALS like a genetic anomaly, oligodendrocyte degradation, demyelination, glial overactivation, immune deregulation, and neuroexcitation

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2 GLP-1R monotherapy (e.g., semaglutide) is highly effective, but dual GLP-1R/GIPR agonists (e.g.,

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