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Contrave remains a strong option for patients who cannot take GLP-1 medications due to gastrointestinal side effects or contraindications, and it is available at a lower cost in many cases

Rare heterozygous loss-of-function variants in the human GLP-1 receptor do not associate with cardiometabolic phenotypes

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Limitations to their use include the possible adverse effects of nausea and diarrhoea (in more than 10% of patients), vomiting, constipation and abdominal pain, which can lead some patients to discontinue therapy