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How can clinicians manage these interactions

They can yield 1520% weight reductions in adults, previously only possible after bariatric surgery (Gross)

Implementation guidance for NHS England proposes a phased rollout of Mounjaro which prioritises patients in greatest need, with an ultimate goal of treating 220,000 patients with Mounjaro in the first three years [6]

As such, these agents are generally contraindicated in patients with a personal or family history of MTC and in patients with multiple endocrine neoplasia syndrome type 2 (MEN2)

The proposed mechanisms by which GLP-1 receptor agonists might influence pancreatic health involve several biological pathways, though none have been conclusively proven to cause pancreatitis in humans