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hazard ratios 1.54-1.95) Masseter domain patients saw their mean duration fall from ~20.1 2.9 weeks in controls to 17.3, 17.0, 16.7 and 16.2 weeks (hazard ratios 1.72-2.08) Sensitivity analysis suggested ~55% of the reduction in duration was attributable to synaptic modulation, ~30% to lean-mass decline, and ~15% to metabolic variability

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