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Phase 2 data suggests retatrutide may produce greater weight reduction than currently approved agents, but its long-term safety profile has not been fully established, and no head-to-head regulatory-grade trials have been completed
These data, in conjunction with our DART-Seq data generated in islets from older human donors, suggest that age and other metabolic stressors may drive cell conversion to compensate for a loss of the cell proliferative response to GLP-1
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Tirzepatide (Zepbound, Mounjaro) Tirzepatide is a first-in-class dual agonist
The mechanisms underlying these effects are particularly intriguing
