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Ozempic and other GLP-1 receptor agonists dampen mesolimbic dopamine signaling, reducing reward salience and drug reinforcement across addictions

While clinical innovation remains important, investors must evaluate not just scientific differentiation, but also commercial execution, payer alignment, and scalability

The top three treatments for DBP reduction according to P-score were orforglipron 24 mg, followed by orforglipron 36 mg, and orforglipron 6 mg (Figure 14)

Emerging research on the gut microbiome and GLP-1 signalling suggests potential interactions

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