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In XIGDUO XR-treated patients with a diagnosis or strong suspicion of lactic acidosis, prompt hemodialysis is recommended to correct the acidosis and remove accumulated metformin (metformin HCl is dialyzable, with a clearance of up to 170 mL/min under good hemodynamic conditions)

The FDA has approved specific GLP-1 formulations for weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity

Change in BMI class was also evaluated

Consult a licensed healthcare provider before starting, stopping, or changing any GLP-1 treatment

Some patients report increased satiety, reduced food cravings, or mild gastrointestinal effects during this overlap period