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Others, such as Exubera (inhaled insulin) failed due to poor market penetration as well as safety concerns associated with drug accumulation in the lungs [217, 218]

Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group
Drucker D

The answer to that question is also a probable yes , but that's the subject of another article
Santo MA, Riccioppo D, Pajecki D, Kawamoto F, de Cleva R, Antonangelo L, Maral L, Cecconello I
