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This association has prompted extensive investigation into the safety profile of these medications, aiming to elucidate the underlying mechanisms and assess the true magnitude of risk

For patients with type 2 diabetes who maintained a stable weight, GLP-1 use was associated with an 8.7% lower osteoporosis risk compared to patients who did not use a GLP-1, as seen in Figure 1

The GLP-1 receptor is involved in regulating blood sugar levels, while the GIP receptor is involved in stimulating insulin secretion and reducing appetite

Hormonal alterations, including reduced gonadal, thyroidal, and somatotropic activity, further impair bone formation and promote catabolism of lean tissues, including bone

Liao, R