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doi: 10.1677/joe.0.1380159 [DOI] [PubMed] [Google Scholar] 57

However, the effects of combinations of multi-receptor agonists in humans can be challenging to predict from animal studies [68]
Semaglutide affects your digestive system, and starting the medication with optimal hydration can significantly reduce the likelihood of early side effects like headaches or mild nausea

doi:10.1038/s41598-024-75965-2 Liao Y, Xie B, Zhang H, et al

For example, they may have read or heard about a newer treatment or may have a preference for one delivery device or route over another
