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The exendin-4 effect was accompanied by an increase in [Ca 2+ ] i of GCs through the IP 3 -sensitive pathway and was blocked in Ca 2+ -free solution
PMID: 39980735
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The UK prospective diabetes study (UKPDS) revealed that age, female sex, poor glucose control, weight, alcohol consumption, and current smoking are risk factors for DPN (39)
Metformin decreases liver uptake of lactate increasing lactate blood levels which may increase the risk of lactic acidosis, especially in patients at risk
