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The secondary aim is to avoid 'additional blows' leading to MASH and acute liver failure and to reduce hepatic fat deposition in patients (234)

Compared to placebo (3.3%, 3.2 kg), patients lost a mean of 13.4% (13.5 kg) of body weight in the 10 mg group and 15.7% (15.6 kg) of body weight in the 15 mg group

As the lymphedema persists for a longer time, the pro-inflammatory cytokines can cause fibrosis thickening or scarring in the area.[ref] Genetic Polymorphisms and Lymphedema: Lymphedema due to physically damaged lymph vessels can happen to anyone, especially after surgery or cancer treatment.[ref] However, some people are more susceptible to secondary lymphedema than others

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According to NICE guidance and clinical trials, clinically meaningful weight loss occurs over several months of treatment, with continued weight reduction possible over 1218 months when combined with lifestyle modifications
