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2026 Update: In the SURMOUNT-5 head-to-head trial, tirzepatide produced ~47% more weight loss than semaglutide over 72 weeks

As featured in Zepbound is FDA-approved tirzepatide from Eli Lilly the first dual-action GLP-1/GIP medication approved specifically for chronic weight management

Some patients report that the oral formulation causes less reflux than injectable semaglutide, while others find the required empty-stomach dosing triggers more morning nausea and reflux