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A phase 2 clinical trial involving 47 patients with PWS revealed that UAG analogue therapy significantly improved food-related behaviors and showed promising metabolic outcomes [55]

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Subsequent meta-analyses of cardiovascular outcomes trials with GLP-1RAs have clearly excluded a causal role for GLP-1RAs in acute pancreatitis (63, 69, 70), while therapy with inhibitors of dipeptidyl peptidase-4 may lead to a minor elevation of this risk (69)

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