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Science 333 , 12621266 (2011)

Topiramate is known to occasionally cause a condition called metabolic acidosis

Among over 500 obese patients with OSAS, long-term tirzepatide treatment led to significant reductions in body weight, AHI, and oxygen desaturation index, with particularly pronounced benefits in patients with concurrent glucose and lipid metabolism abnormalities (52)

A physician got the idea to combine them

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