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However, the role of circulating GLP-1 in maternal energy metabolism remains largely unknown

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Storage and handling Keep refrigerated at 28C

From a practical standpoint, healthcare providers may consider this combination in select cases through individualized risk-benefit assessment, but several important factors warrant careful consideration: Overlapping gastrointestinal side effects may significantly impact tolerability Cost considerations , as both medications can be expensive Lack of evidence demonstrating additive benefits Monitoring requirements for both medications Drug interactions with other medications (orlistat may interact with warfarin, requiring INR monitoring

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