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Participants often find it difficult to continue with the healthy habits practiced during the intervention, especially without continued support for maintenance

Treg cells not only interacted with microglia (75), but also regulated the polarization transformation of microglia from M1 to M2 type (28, 80, 81)

GLP-1 capsule is an intestinal insulinotropic hormone secreted by intestinal L cells, whose core function is to regulate energy metabolism through a "glucose dependent" mechanism

It should also be noted that these trials predominantly included relatively healthy older participants, as individuals with potential comorbidities such as cardiovascular or renal diseases were often excluded [12, 34]

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