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Knudsen and her colleagues also recognized and began studying the powerful weight loss effects of liguratide, and they discovered that it binds to neurons in the arcuate nucleus, a region of the brain involved in regulating food intake and energy expenditure (4)

For example, when rats are offered unlimited access to diets enriched in fat, carbohydrate, or protein, intra-VTA infusion of the GHSR antagonist GHRP over 14 days specifically lowers fat intake [77]

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