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However, not all triple GLP-1/GIP/GCG agonists are advancing to late-stage clinical trials

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Patients may experience stomach upset, nausea, or changes in bowel habits that make it difficult to distinguish which medication is responsible, complicating dose adjustments and compliance

Specifically, Asp 21P forms a salt bridge with R242 ECL1 , while Trp 25P forms a hydrogen bond with D244 ECL1 and pi-pi stacking with W249 ECL1 , which was stabilized by Phe 22P