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This mechanism creates the appetite-suppressing effect that makes GLP-1s effective for weight loss

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Karnchanasorn R, Huang J, Ou HY, et al

Men experience loose skin or stubborn fat after significant weight drops

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In contrast to findings with behavioral 20,21,22 and other pharmacological interventions 10,12,13 , the similar mean weight loss achieved with semaglutide 2.4 mg in STEP 5 at weeks 52 and 104 (15.6% and 15.2%, respectively) suggests that, on average, there is minimal weight regain over 104 weeks when once-weekly semaglutide therapy is continued