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Using rodent models of obesity and metabolic dysfunction, the research group demonstrated that the triple-agonist approach produced meaningful reductions in body weight and improved glycaemic parameters compared to both placebo and comparator compounds targeting fewer receptors

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Both medications are metabolized primarily by your liver through cytochrome P450 pathways, but they use different enzyme familieshydroxyzine uses CYP3A4 and CYP2D6, while semaglutide undergoes hydrolysis and transaminase metabolism