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In the SURPASS-1 to 5 trials (N = 6263), nausea (12%24%), diarrhea (12%22%), and vomiting (2%13%) were the most common gastrointestinal ADEs associated with tirzepatide ( The FDA Adverse Event Reporting System (FAERS) database is an invaluable resource for post-marketing surveillance and early detection of drug safety issues

Patient monitoring should include: Baseline lipid panel, hemoglobin A1c, and liver function tests Blood pressure monitoring (GLP-1 agents typically reduce systolic BP by 3-5 mmHg) [10] Assessment for gastrointestinal adverse effects during dose titration Evaluation for contraindications (personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2) [1] [3] Monitoring for gallbladder disease (increased risk with rapid weight loss) In patients with diabetes and retinopathy, monitoring for worsening eye symptoms, particularly with rapid glycemic improvement Renal function assessment, especially if severe gastrointestinal symptoms cause dehydration Patients should seek immediate medical attention for severe abdominal pain, which may indicate pancreatitisa rare but serious adverse effect

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