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There is a black box warning for this class regarding the risk of osteosarcoma (bone cancer), which has been observed in animal models at high doses
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Chia and flax, in particular, form a gel when mixed with liquid, slowing gastric emptying and the absorption of sugar into the bloodstream
2025;37(3):592e6056
While a causal relationship remains inconclusive (patients with T2D and obesity have other pancreatitis risk factors), prudence dictates avoiding these drugs in patients with a history of pancreatitis or at least using with caution
