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As a review in The Analytical Scientist published in January 2026 noted, lipidation modifications "significantly increase the complexity of analytical workflows," introducing additional critical quality attributes that must be carefully monitored and controlled throughout the manufacturing process and into final release testing
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This approach common to GLP-1 and related receptor agonist therapies is designed to minimise gastrointestinal side effects such as nausea, vomiting, and diarrhoea, which are among the most frequently reported adverse events with this class of medication

doi: 10.1210/en.2014-1978
