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However, these over-the-counter products are not FDA-approved medications and contain no actual GLP-1 receptor agonists

This wasnt surprising since the gut was the first organ to develop, well before the pancreas, liver, or brain

Despite this, a meta-analysis in 2016 found that 19 out of 21 studies that measured the effect of GLP-1 RA against a comparator found no significant changes in TL [69]

This is important because it suggests that glucagon receptor activation, when balanced by incretin co-agonism, does not automatically negate glycemic benefit

It usually means the medication is doing what it's supposed to do, and your body needs a few weeks to catch up