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First, neurons expressing LepR are not sensitive enough to measure the circulating leptin level, decreasing the efficacy of leptin binding to LepR

Specifically, it slows gastric emptying (so you feel full longer), increases insulin release, reduces glucagon levels, and suppresses appetite

Weight Changes: As noted above, semaglutide can lead to weight loss, which can have negative mental health implications

CDC data show rising GLP-1 use as part of diabetes therapy, reflecting guideline adoption

When a new prescription drug enters the market, the question for employers isnt just does it work? Its what does covering it mean for our people, our plan, and our longterm costs? That question became especially relevant in early 2026, when an oral version of Wegovy entered the market with widespread media coverage