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Continue your surveillance as scheduled

This can lead to increased food intake and rapid regain of lost weight

Observational studies have associated alterations in cortisol patterns, such as flattened diurnal curves or elevated evening levels, with obesity, metabolic syndrome, and cardiovascular risk, though these findings do not establish causality

Do not stop taking any trial medication without first consulting your trial team, as abrupt discontinuation may have its own implications and must be managed in accordance with the trial protocol

The standard protocol starts tirzepatide at 2.5 mg regardless of prior semaglutide dose, then escalates every 4 weeks based on tolerance