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In the same FDA drug safety communication, post-marketing cases of urosepsis and pyelonephritis were discussed, leading to the addition of warnings of severe infections to the prescribing information for these products

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Other GLP-1RAs (liraglutide) also elevated phosphorylation of ERK with increased transcriptional activity and the inhibitors of PD98059 and GLP-1R siRNA partially blocked the liraglutide-induced ERK signaling activation (Wu et al., 2017)