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In addition, Excess ROS production has deleterious effects on mitochondrial components such as mitochondrial DNA, mitochondrial proteins, lipids, and respiratory chain functions, leading to insufficient energy supply for cells, triggering more ROS generation and disturbances in calcium homeostasis, thus creating a mitochondrial free radical vicious cycle of injury (Yang et al., 2020)

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Yellowing of skin or eyes (jaundice) in severe cases

The appetite-suppressing and GI-motility-altering effects of GLP-1 receptor agonists can reduce salivary flow in some patients, potentially exacerbating Sjogren's oral symptoms

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