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Optimizing gastrointestinal tolerability is a critical aspect of drug development to minimize discomfort and improve patient adherence, especially when considering escalating doses

You'll hear those that swear it changed their life and others who shun it as another unnecessary medication promoting diet culture

found that GLP-1 RAs are associated with an increased risk of gallbladder and biliary diseases (including cholelithiasis and cholecystitis), particularly at higher doses, longer treatment durations, and when used for weight loss [129]

[1] [8] The European Medicines Agency (EMA) European Public Assessment Report (EPAR) for Rybelsus similarly does not highlight thrombotic events as a safety concern

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