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Managing Expectations and Maintaining Weight Loss Long-Term Weight loss on semaglutide is not linear, and plateaus of 2-4 weeks without scale movement are completely normal as your metabolism adjusts

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STEP trial participants who reached the 2.4 milligram weekly dose lost an average of 22% of their body weight over 68 weeks, while lower-dose cohorts saw proportionally less dramatic results

Semaglutide FDA product information (2023)

Analysis of over 80,000 electronic health records found that patients prescribed semaglutide for obesity had a 50-56% lower risk of developing alcohol use disorder compared to those on other anti-obesity medications