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suspected side effects can also be reported to the MHRA via the Yellow Card Scheme

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How It Works (Dual Action Mechanism) Tirzepatide activates two incretin hormone receptors: GLP-1 (Glucagon-like Peptide-1) Reduces appetite Slows stomach emptying Improves insulin release GIP (Glucose-dependent Insulinotropic Polypeptide) Boosts insulin secretion when glucose is present Improves fat metabolism Acts with GLP-1 to improve weight loss strength Together, they create better glucose control and stronger appetite suppression than GLP-1 alone

During 2024 and 2025, the GLP-1 class was increasingly defined by expanded use cases and approvals, with existing drugs gaining indications including cardiovascular risk, sleep apnea and kidney disease