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For patients concerned about losing lean muscle mass while using semaglutide or tirzepatide, however, there is some good news: A new study conducted by obesity specialists in New York found that incorporating resistance training, increasing protein intake, and reducing the speed of weight loss can mitigate the risk of GLP-1-associated muscle loss

At present, combination with DPP-4 inhibitors is not recommended, despite the significant glycemic improvement, in view of the enhanced hypoglycemic effects

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Excess adipose tissue increases joint loading, especially in weight-bearing joints like the knees and hips

Adverse effects can include: Rarely, people using GLP-1 agonists have experienced severe pancreas damage