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FIGURE 3 TABLE 4 Top 50 signal intensity of ADEs of tirzepatide ranked by EBGM at the PT level
All doses of tirzepatide and semaglutide were superior to placebo in achieving at least a 10% body weight reduction, with tirzepatide 15 mg (risk ratio = 10.51 [95% CI 7.55, 14.64]) and tirzepatide 10 mg (risk ratio = 8.84 [95% CI 6.35, 12.32]) being the most efficacious treatments (ESM Table 13)

By engaging GIP simultaneously, it modulates appetite regulation, glucose handling, and energy storage through complementary pathways

IP) reward responses in male mice

This ratio holds remarkably consistent across all dose groups and is comparable to what occurs with any form of caloric restriction, whether pharmaceutical or dietary
