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2017;96(3):e5921

These signals say as much about reliability as any glitzy promotion could

GI symptoms, if present, typically peak during week two and begin improving by week three as the body adjusts

Although, as said above, weight loss induced by GLP-1 RAs comes mainly from reductions in fat mass rather than lean mass, nutritional advice and exercise programmes to achieve muscle strengthening are recommended to minimize sarcopenic risk [74]

Additionally, if the mechanism of action of the peptide drug can alter the pharmacokinetics of other co-administered drugs, it is recommended that the sponsor evaluate the peptide drug as a perpetrator