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Large-scale pharmacoepidemiological data has not demonstrated a statistically significant increase in suicidal behaviour but there are important signals in specific subgroups, particularly those already on antidepressants or benzodiazepines

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Semaglutide has shown strong safety and efficacy data in clinical trials for weight loss

Larger, mechanistically enriched trials are warranted to validate efficacy and guide clinical translation for nicotine dependence and related substance use disorders.