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SURPASS Diabetes Trials SURPASS-1 through SURPASS-5 enrolled thousands of participants with type 2 diabetes, consistently demonstrating superior HbA1c reductions compared to placebo, semaglutide, and insulin glargine

And it acts on brain regions involved in satiety, particularly the hypothalamus and brainstem

The starting dose of 2.5 mg is primarily for tolerability rather than maximum efficacy, with gradual titration every 4 weeks minimizing gastrointestinal adverse effects like nausea and vomiting

Making the decision: Whether to use Mounjaro while breastfeeding is best decided with your healthcare professional, weighing the importance of good diabetes control against the current evidence, which indicates only minimal transfer into breast milk
