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The authors used a conjugate of Ex4 and vitamin B 12 to produce a GLP1 receptor agonist without brain penetrance (Borner et al., 2020
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North America exhibited the highest incidence of reported psychiatric AEs ( n = 7,673, 93.12%), which could potentially be attributed to its leading number of prescriptions for GLP-1 RAs, followed by Europe ( n = 299, 3.63%) and Asia ( n = 137, 1.66%)
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