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Slower Satiety Signals: Leptin (the Im full hormone) and cholecystokinin (CCK, released by fats and proteins) take longer to kick in without GLP-1s boost, making overeating easier

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Semaglutide may cause nausea, vomiting, and gastrointestinal issues

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Clinical trial data reveals that patients maintaining a 2.4 mg weekly dose lose approximately 1618% of their body weight over 68 weeks when combined with lifestyle modifications, compared to roughly 3% in placebo groups