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Each dose level is held for at least 4 weeks before moving up

Two trials, the AHEAD Study (lecanemab) and TRAILBLAZER-Alz-3 (donanemab), are now in the process of evaluating the effect of these therapies on the prevention of disease progression in people at high risk of AD, as measured by time to clinical progression (AHEAD Study, 2024

They also adjusted for factors that could potentially skew the results, such as age, sex and how long they'd had diabetes

Mitochondrial dysfunction, oxidative stress, and inter-organ miscommunications in T2D progression

A 2024 study led by Wang, Volkow, and colleagues examined two cohorts totaling over 682,000 individuals with either obesity or type 2 diabetes and found the risk of new alcohol use disorder diagnoses was about 50% lower among those taking semaglutide compared to other anti-obesity or diabetes medications (Wang et al., 2024a)