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Med Rev 2024;4(4):30111 Heymsfield SB, Gonzalez MC, Shen W, Redman L, Thomas D (2014) Weight loss composition is one-fourth fat-free mass: a critical review and critique of this widely cited rule

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GLP-1R works through the combination of the endogenous ligand Glucagon-like peptide-1 (GLP-1) or exogenous agonists, which activate multiple intracellular signaling pathways that enhance insulin secretion, inhibit glucagon secretion, protect -cells from apoptosis, delay gastric emptying and increase satiety