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Cosmos Study January 23, 2024 Dual-Team Study Team A:Kersten Bartelt, RNChris Mast, MDJoe Deckert, PhD Team B:Matthew Gracianette, MDBrendan Joyce Key Findings More than half of patients are able to maintain weight loss achieved while on semaglutide or liraglutide even a year after discontinuing the medication

All patients with CKD should work with a registered dietitian and nephrologist to determine appropriate protein levels

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Semaglutide dosing protocol The standard semaglutide titration for weight management follows a well-established 16-20 week escalation schedule: Weeks 1-4: 0.25 mg once weekly Weeks 5-8: 0.50 mg once weekly Weeks 9-12: 1.0 mg once weekly Weeks 13-16: 1.7 mg once weekly Week 17 onward: 2.4 mg once weekly (maintenance dose) This graduated approach serves two purposes

Over one-half of new prescriptions for novel/new medicines go unfilled, and only 31% of patients stayed on-therapy for one year