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Attempts to determine this mechanism without PKA have indicated that GLP-1 and Exenatide produce low amounts of cAMP, while IBMX and forskolin produce higher cAMP, activating the cAMP pathway [58]

[DOI] [PMC free article] [PubMed] [Google Scholar] 571.Herzberg-Schafer S., Heni M., Stefan N., Haring H.U., Fritsche A

However, given the novelty of this therapeutic approach, the available evidence may be influenced by publication bias and early optimism, and long-term mechanistic and clinical outcome data remain limited

Eligibility assessments, dosing decisions, and continuation protocols are managed within a clinical framework that prioritizes patient safety and metabolic appropriateness

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