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However, the most effective APs carry a higher risk of weight gain [4, 5], which can result in severe general adverse health effects [6]

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And from mechanistic standpoint, everything we talked about previously about what estrogen does and how changing estrogen changes our metabolism, I think you can start to piece together like why this might be a good idea

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[12] [13] Red flags that require urgent medical attention include unexplained weight loss, fever, focal neurological deficits, or inflammatory joint swelling, as these may indicate alternative diagnoses requiring different management