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However, this increase appears to be due to the rapid and robust glucose-lowering in people with marked hyperglycemia and preexisting retinopathy phenomenon previously observed in studies of insulin

159,160,161,162 Studies have shown that Lactobacillus can upregulate tight junction proteins, protect the integrity of the epithelial barrier, and enhance the function of the intestinal barrier by regulating the expression of aryl hydrocarbon receptors and NRF2

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The therapeutic advantages of GLP-1 agonists emerge from weight reduction of 1215% along with decreased hs-CRP levels and enhanced endothelial function [12]