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Risk-Benefit Assessment : The potential benefits must be carefully weighed against known and unknown risks, particularly given the limited long-term safety data in adolescents

However, they should not be used with DPP-4 inhibitors (such as sitagliptin), and insulin or sulphonylurea doses may need adjustment to prevent hypoglycaemia

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Zepbound began competing with Wegovy on efficacy, Mounjaro became a powerful diabetes product, and now Retatrutide adds another argument in Lilly's favour

Protein optimization is particularly important during this transition